Dendy
Systems For Intrapleural Gene Therapy for Mesothelioma Considered
Japanese mesothelioma researchers say a highly specialized type of therapy that presents gene changing compounds into the intrapleural space around the lungs has precise �distinct aspects� that set it aside from other mesothelioma treatment options. The report, which appears in the recent installment of Cancer Gene Therapy, includes an investigation of clinical and preclinical trials of mesothelioma gene therapy. In accordance with the researchers from the Chiba Cancer Center Research Institute and Chiba University Medical School, a no of studies have discovered that most mesothelioma tumors exhibit a genetic defect through which the tumor-fighting p53 gene pathway is �turned off�. Turning this pathway back on, by delivering gene-altering compounds into mesothelioma cells with help from modified viruses, can be shown to have an anti-tumor effect. Moreover, the authors of the new report say there may be now evidence that this anti-tumor effect may be heightened by delivering the adenoviruses (known as viral vectors) close to the mesothelioma tumor in the intrapleural space. Not only does this delivery method lessen the effect of treatment on healthy cells, but it may be especially valuable in mesothelioma since this type of cancer does not usually spread to extrapleural organs. However, as the study�s authors say, the technique also has drawbacks. �Intrapleural administration of vectors has several advantages in transducing pleural mesothelioma but activates quick antibody production which impedes further gene expression,� they write. Further study is needed to balance the advantages and problems of this advanced mesothelioma treatment technique. Mesothelioma is caused almost exclusively by exposure to asbestos or a similar mineral called erionite. Although it can take decades after exposure for symptoms to mature, once they are doing, the disease tends to spread quickly. There's presently no cure for mesothelioma. Disclaimer: The knowledge in this information is for educational and informational purposes only. The content isn't intended to become a substitute for professional medical advice, diagnosis, or treatment. Always seek the recommendation of a medical doctor or other qualified health provider with any questions you could have regarding a medical condition. Never disregard professional medical advice or delay in seeking it due to something you've read during this article. This article was written by a third party and its content reflects the views of the third party and does not necessarily reflect the views or opinions or of Surviving Mesothelioma or Cancer Monthly.