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A Background In Painless Mesothelioma Outcomes and Hormones Solutions

Although it isn't generally regarded as a hormone-linked cancer like breast or ovarian cancer, an innovative study suggests that malignant peritoneal mesothelioma might have a hormonal constituent. Researchers in Australia came up with the idea after noticing that women with peritoneal mesothelioma often survive for a longer time than men with the condition.

Women have higher levels of estradiol, a form of estrogen produced from the ovaries and adrenal gland and, to a lesser degree, by metabolism of testosterone. Estradiol is shown in other studies to be connected to the growth of several varieties of cancer, including non-small cell lung cancer. The hormone exerts its influence in our bodies by binding with estrogen receptors within the cells.

The new report finds that not only the presence of estradiol, but the presence and site of those estrogen receptors may impact on mesothelioma outcomes. Researchers measured estrogen receptor levels in 42 peritoneal mesothelioma sufferers. 33 patients had the beta variety of estrogen receptor (ER-?) within the nucleus of these cells. The remaining 9 patients had higher ER-? concentrations primarily outside the nucleus inside the cytoplasm of their cells. These patients tended to have poorer outcomes.

�The presence of ER-? (cytoplasm) is linked to poor prognosis,� conclude the authors in the Journal of Cancer Research and Clinical Oncology. �The favourable survival association observed in patients with ER-? (nuclear) raises a question regarding the molecular mechanisms of the tumorigenic roles of ER-? in each cellular compartment and requires further scientific studies.�

While it may never be possible to manipulate mesothelioma outcomes by manipulating hormones, prognostic indicators such as estrogen receptors can be used to help guide mesothelioma treatment planning. Mesothelioma is an aggressive malignancy that usually doesn't respond well to established therapies. A tailored, multi-modality treatment approach, based on patient history, age, gender, overall health, and other prognostic factors, has been shown to produce the most effective outcomes.

Disclaimer: The information in this article is for educational and informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read in this article. This article was written by a third party and its content reflects the views of the third party and does not necessarily reflect the views or opinions or of Surviving Mesothelioma or Cancer Monthly.

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